Mtskheta was the ancient capital of Kartli, the East Georgian Kingdom from the 3rd century BC to the 5th century AD, and was also the location where Christianity was proclaimed as the official religion of Georgia in 337. To date, it still remains the headquarters of the Georgian Orthodox and Apostolic Church.

The favourable natural conditions, its strategic location at the intersection of trade routes, and its close relations with the Roman Empire, the Persian Empire, Syria, Palestine, and Byzantium, generated and stimulated the development of Mtskheta and led to the integration of different cultural influences with local cultural traditions. After the 6th century AD, when the capital was transferred to Tbilisi, Mtskheta continued to retain its leading role as one of the important cultural and spiritual centres of the country.